Effect of the plant flavonoid, rhoifolin, on memory and cognition in a rat model of Alzheimer’s disease
نویسندگان
چکیده
Purpose: To investigate the neuroprotective effect of natural flavonoid rhoifolin in rats with streptozotocin (STZ)-induced (AD).
 Methods: Morris water-maze and novel object recognition tests were carried out to estimate on memory cognition. Histopathological analysis was made observe thickness hippocampal CA1 pyramidal layer. Analysis oxidative stress markers performed hippocampus frontal cortex.
 Results: water maze showed a significant improvement memory, cognition spatial learning treated AD animals (p < 0.05). Moreover, treatment resulted increase layer indicating its properties The area further validated reversal cognitive dysfunctions caused by STZ treatment. Furthermore, SOD, CAT, GPX, GRX, MDA cortex 0.05).
 Conclusion: present study is first report demonstrate plant flavonoid, STZ-induced rat model. Rhoifolin improves learning, cognition, STZ-treated Therefore, may be promising therapeutic agent for management AD.
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ژورنال
عنوان ژورنال: Tropical Journal of Pharmaceutical Research
سال: 2022
ISSN: ['1596-5996', '1596-9827']
DOI: https://doi.org/10.4314/tjpr.v20i7.22